CHEMMAT 753

Biomaterials and Applications

Summary


Semester

Semester 1, 2019

Staff

Contents


Calendar notes

Biological materials: form, structure and function; formation, growth and development; repair, replacement and regeneration. Biomaterials: applications of hydrogels, elastomers, metals, ceramics, bio-resorbable materials, biomaterial surface modifications.
Prerequisite: BIOMENG 221, or CHEMMAT 204 and 205, or CHEMMAT 221 and 232Restriction: CHEMMAT 422

Outcome mapping


Intended learning outcomes
Related graduate attributes
Related assessments

1. Hierarchical structure of biological materials (approximately 4 lectures) Learning Outcomes: At the end of this part you should be able to: [1] Describe the concept of hierarchical organisation and discuss its functional relevance. (IIA-3; IIC) [2] Answer specific questions about the way in which collagen is synthesised, assembled and structurally organised for the various forms and functions of connective tissue. (IA-5; IIA-2) [3] Show how in nature the principles of hierarchical organisation are widely applied. (IIC) • UOA_1 Discipline knowledge and practice • ENG: A01 Engineering knowledge • ICHEME A.2.2 Fundamentals • ICHEME A.5.1 Principles of systems

ENGA01: engineering knowledge (4)
ICHEME A2.2.2: Thermodynamics and transport (1)
ICHEME_A2.5.1: Principles of systems (0)
UOA_1: Disciplinary Knowledge and Practice (4)

No related assessments

2. Mechanical Characterisation of biological materials (2 lectures) Learning Outcomes: At the end of this part you should be able to: [1] List the general structural and mechanical characteristics of tendons, ligaments, cartilage and bone. (IIA – 2,3; IIB; IIIA; IIIB) [2] Describe biological materials in relation to its properties (e.g. Stiffness, strength, viscoelastic behaviour) and how such properties of these materials may be studied experimentally. (IIB; IIIB) •

ENGA01: engineering knowledge (4)
ICHEME_A 2.2.: Fundamentals (3)
UOA_1: Disciplinary Knowledge and Practice (4)

No related assessments

3. Formation, growth and development of tissue structures (2 lectures) Learning Outcomes: At the end of this part you should be able to: [1] Articulate clearly Wolff’s law and describe the functional adaptation of bone. (IIA – 4,5,6; IIB – 2, 3) [2] Show by clear comparisons the differences between the development of biological and engineering materials, in relation to the elements used and modes of fabrication. (IIC – 1, IIIC – 1, IC-3,4; IIC 2,3,4 )

ICHEME A2.2.2: Thermodynamics and transport (1)
ICHEME_A41: Innovation and diversity (1)
UOA_1: Disciplinary Knowledge and Practice (4)

No related assessments

3. Formation, growth and development of tissue structures (2 lectures) Learning Outcomes: At the end of this part you should be able to: [1] Articulate clearly Wolff’s law and describe the functional adaptation of bone. (IIA – 4,5,6; IIB – 2, 3) [2] Show by clear comparisons the differences between the development of biological and engineering materials, in relation to the elements used and modes of fabrication. (IIC – 1, IIIC – 1, IC-3,4; IIC 2,3,4 )

ICHEME A2.2.2: Thermodynamics and transport (1)
ICHEME_A41: Innovation and diversity (1)
UOA_1: Disciplinary Knowledge and Practice (4)

No related assessments

4. Models of tissue growth, development and development (1 lecture) Learning Outcomes: At the end of this part you should be able to: [1] Describe the important bone forming processes. (IIA -2) [2] Describe bone remodelling (IIA – 9) [3] Explain the inter-fragmentary bone strain theory (IIA –5, 9)

ENGA01: engineering knowledge (4)
ICHEME_A 2.2.: Fundamentals (3)
ICHEME A2.2.2: Thermodynamics and transport (1)
ICHEME_A41: Innovation and diversity (1)
UOA_1: Disciplinary Knowledge and Practice (4)

No related assessments

5. Adaptation to mechanical environment (2 lectures) Learning Outcomes: At the end of this part you should be able to: [1] Define mechanobiology (IIA-5) [2] State the various mechanical stimuli associated with musculoskeletal tissue differentiation. (IA – 7, IIA – 5) [3] Explain how structural realties at different scalar levels may influence tissue adaptation to the mechanical environment (IIC - 2,3,4)

ENGA01: engineering knowledge (4)
ICHEME A2.2.2: Thermodynamics and transport (1)
ICHEME_A41: Innovation and diversity (1)
UOA_1: Disciplinary Knowledge and Practice (4)

No related assessments

6. Hard tissue replacements (1 lecture) Learning Outcomes: Lecture 1: Introduction to the course and a history of biomaterials Learning outcomes At the end of this session students should: [1] Have an introductory understanding of what biological and biomaterials and be aware of definitions of key terms used (biomaterial, biocompatibility,etc) [2] Have some knowledge of the history of biomaterials.

ENGA01: engineering knowledge (4)
UOA_1: Disciplinary Knowledge and Practice (4)

No related assessments

Overview of physiology and pathophysiology Learning outcomes At the end of this session students should: [1] Describe what is meant by physiology, homeostasis and emergent properties [2] Know the main organ systems in the human body [3] Understand and be able to list the hierarchical scales of biology [4] Be familiar with key reasons for biomaterials successes and failures

ENGA01: engineering knowledge (4)
ICHEME A2.2.2: Thermodynamics and transport (1)
ICHEME_A2.5.1: Principles of systems (0)
UOA_1: Disciplinary Knowledge and Practice (4)

No related assessments

Overview of physiology and pathophysiology Learning outcomes At the end of this session students should: [1] Describe what is meant by physiology, homeostasis and emergent properties [2] Know the main organ systems in the human body [3] Understand and be able to list the hierarchical scales of biology [4] Be familiar with key reasons for biomaterials successes and failures

ENGA01: engineering knowledge (4)
ICHEME A2.2.2: Thermodynamics and transport (1)
ICHEME_A2.5.1: Principles of systems (0)
UOA_1: Disciplinary Knowledge and Practice (4)

No related assessments

Biomaterials – materials used in medicine Learning outcomes [1] At the end of this session students should: [2] Be able to list the types of biomaterials and the properties that make them useful as a biomaterial [3] Be able to use CES Edupack to investigate properties of biomaterials

ENGA01: engineering knowledge (4)
ENGA04: investigation (1)
ENGA05: modern tool usage (1)
ICHEME A2.2.2: Thermodynamics and transport (1)
ICHEME_A2.4.1: Process and product technology (1)
UOA_1: Disciplinary Knowledge and Practice (4)
UOA_2: Critical Thinking (2)

No related assessments

: The body’s response to biomaterials Learning outcomes At the end of these sessions students should: [1] Be able to describe the inflammatory process [2] Understand innate and adaptive immunity and the role of the complement system [3] Describe the process of wound healing [4] Be able to give examples of blood-material interactions and examples of blood contacting devices

ENGA01: engineering knowledge (4)
ENGA10: communication (2)
ICHEME_A 2.2.: Fundamentals (3)
ICHEME_A2.5.1: Principles of systems (0)
UOA_1: Disciplinary Knowledge and Practice (4)

No related assessments

: Degradation of biomaterials and case studies Learning outcomes At the end of these sessions students should: [1] Be able to describe the mechanisms of degradation of biomaterials At the end of these sessions students should: [1] Be able to list the key reasons for biomaterial failures [2] Know how to access the FDA website listing biomaterial failures

ENGA01: engineering knowledge (4)
ENGA10: communication (2)
ICHEME A2.2.2: Thermodynamics and transport (1)
UOA_1: Disciplinary Knowledge and Practice (4)
UOA_2: Critical Thinking (2)

No related assessments

: Computational modelling Learning outcomes At the end of these sessions students should: [1] Be able to describe the benefits of computational modelling [2] Describe methods used for biomechanical modelling •

ENGA01: engineering knowledge (4)
ENGA05: modern tool usage (1)
ICHEME_A 2.2.: Fundamentals (3)
ICHEME A3.2.2: Chemical Engineering Practice- professional roles (1)
UOA_1: Disciplinary Knowledge and Practice (4)
UOA_2: Critical Thinking (2)
UOA_5: Independence and Integrity (1)

No related assessments

Infection and biomaterial sterilisation techniques Learning outcomes At the end of these sessions students should: [1] Describe why biomaterials are prone to infection and ways to reduce this danger [2] Be able to describe at least two different sterilisation technologies

ENGA01: engineering knowledge (4)
UOA_1: Disciplinary Knowledge and Practice (4)

No related assessments

Taking biomaterials to the clinic Learning outcomes At the end of these sessions students should: [1] Know the key ethical considerations around biomaterials [2] Be familiar with the regulatory framework for moving medical devices to the clinic •

ENGA06: engineering and society (2)
ENGA08: ethics (1)
ICHEME A2.6.2: Risk assessment (1)
ICHEME A2.6.3: Identifying and assessing hazards including specialist aspects (2)
ICHEME A2.6.4: Safety legislation framework and its application (1)
ICHEME A 2.7.4: Ethics (1)
ICHEME A3.2.2: Chemical Engineering Practice- professional roles (1)
UOA_1: Disciplinary Knowledge and Practice (4)
UOA_4: Communication and Engagement (2)
UOA_6: Social and Environmental Responsiblities (1)

No related assessments

Taking biomaterials to the clinic Learning outcomes At the end of these sessions students should: [1] Know the key ethical considerations around biomaterials [2] Be familiar with the regulatory framework for moving medical devices to the clinic •

ENGA06: engineering and society (2)
ENGA08: ethics (1)
ICHEME A2.6.2: Risk assessment (1)
ICHEME A2.6.3: Identifying and assessing hazards including specialist aspects (2)
ICHEME A2.6.4: Safety legislation framework and its application (1)
ICHEME A 2.7.4: Ethics (1)
ICHEME A3.2.2: Chemical Engineering Practice- professional roles (1)
UOA_1: Disciplinary Knowledge and Practice (4)
UOA_4: Communication and Engagement (2)
UOA_6: Social and Environmental Responsiblities (1)

No related assessments

Transcription/translation and protein structure At the end of these lectures, the students should be able to: 1) Explain how proteins are made from DNA (the central dogma) and understand the important levels of control. (IA 1,2, 3, 5) 2) Understand protein structural levels and the bonding and driving forces involved. (IA 1,5) 3) Know what conditions generally make proteins unstable and understand the underlying reasons. (IA 1,5)

ENGA01: engineering knowledge (4)
ICHEME A2.2.2: Thermodynamics and transport (1)
UOA_1: Disciplinary Knowledge and Practice (4)

No related assessments

Cells’ surroundings At the end of this lecture, the students should: 1) Understand the importance of cells in our tissues. (IA 4) 2) Know the difference between a stem cell and a differentiated cell type. (IA 4, IC 5) 3) Know the basic constituents of the extracellular matrix. (IA 8, 6) 4) Know the different ways cells receive signals from their surrounding and how they can remodel their surrounding. (IA 5, 7, 8) 5) Understand the concept of mechanotransduction. (IA 7)

ENGA01: engineering knowledge (4)
ICHEME A2.2.2: Thermodynamics and transport (1)
UOA_1: Disciplinary Knowledge and Practice (4)

No related assessments

The Material-Protein and Material-Cell interface At the end of this lecture, the students should: 1) Be able to describe the key components of the tissue-material interface. (IC 3, IA5, IA4) 2) Understand key properties of surfaces, proteins and biological fluids that influence the nature of protein adsorption to surfaces. (IC3, IC6) 3) Understand how surface properties influence cell adhesion and behaviour. (IC3)

ENGA01: engineering knowledge (4)
ICHEME A2.2.2: Thermodynamics and transport (1)
UOA_1: Disciplinary Knowledge and Practice (4)

No related assessments

Microscopy At the end of this lecture, the students should: 1) Have a good overview of microscopy and scanning probe techniques. (IB 7, 8, 1, 2) 2) Know the advantages and disadvantages of each technique and be able to suggest the most suitable technique for model problems. (IB 7, 8, 1, 2)

ENGA01: engineering knowledge (4)
ENGA05: modern tool usage (1)
ICHEME_A 2.2.: Fundamentals (3)
ICHEME_A3.2.1: Chemical engineering practice-lab practice (0)
UOA_1: Disciplinary Knowledge and Practice (4)
UOA_2: Critical Thinking (2)
UOA_3: Solution Seeking (1)

No related assessments

Surface sensitive techniques At the end of this lecture, the students should: 1) Understand the principle, advantages and disadvantages of the presented surface sensitive techniques. (I B 9) 2) Be able to explain how these techniques can be applied to problems in the biomaterials field. (I B 9)

ENGA01: engineering knowledge (4)
ICHEME A2.2.2: Thermodynamics and transport (1)
UOA_1: Disciplinary Knowledge and Practice (4)

No related assessments

Soft tissue replacements At the end of this lecture, the students should: 1) Be able to demonstrate their knowledge of materials used in soft tissue replacements.(II C 1; IIIC 1, 3, 4) 2) Be able to discuss advantages and disadvantages of various materials in the context of soft tissue replacements. (II C 1; IIIC 1, 3, 4) 3) Be able to suggest desirable material properties for various soft-tissue repairs/replacements. (II C 1; IIIC 1, 3, 4)

ENGA01: engineering knowledge (4)
ICHEME_A 2.2.: Fundamentals (3)
UOA_1: Disciplinary Knowledge and Practice (4)
UOA_2: Critical Thinking (2)

No related assessments

Soft tissue replacements At the end of this lecture, the students should: 1) Be able to demonstrate their knowledge of materials used in soft tissue replacements.(II C 1; IIIC 1, 3, 4) 2) Be able to discuss advantages and disadvantages of various materials in the context of soft tissue replacements. (II C 1; IIIC 1, 3, 4) 3) Be able to suggest desirable material properties for various soft-tissue repairs/replacements. (II C 1; IIIC 1, 3, 4)

ENGA01: engineering knowledge (4)
ICHEME_A 2.2.: Fundamentals (3)
UOA_1: Disciplinary Knowledge and Practice (4)
UOA_2: Critical Thinking (2)

No related assessments

Functional surfaces At the end of this lecture, the students should: 1) Have an overview of approaches to create functional surfaces, and how these can be applied in the biomaterials field. (I C2) •

ENGA01: engineering knowledge (4)
ICHEME A2.2.2: Thermodynamics and transport (1)
UOA_1: Disciplinary Knowledge and Practice (4)

No related assessments

Functional surfaces At the end of this lecture, the students should: 1) Have an overview of approaches to create functional surfaces, and how these can be applied in the biomaterials field. (I C2) •

ENGA01: engineering knowledge (4)
ICHEME A2.2.2: Thermodynamics and transport (1)
UOA_1: Disciplinary Knowledge and Practice (4)

No related assessments

Functional surfaces At the end of this lecture, the students should: 1) Have an overview of approaches to create functional surfaces, and how these can be applied in the biomaterials field. (I C2) •

ENGA01: engineering knowledge (4)
ICHEME A2.2.2: Thermodynamics and transport (1)
UOA_1: Disciplinary Knowledge and Practice (4)

No related assessments

Tissue engineering At the end of this lecture, the students should: • Be able to explain the principle of tissue engineering and the components required. (I A4-5, II C1-6, III C4) • Be able to discuss the advantages and disadvantages of tissue engineering. (I A4-5, II C1-6, III C4) • Be able to describe examples of tissue engineered medical devices. (I A4-5, II C1-6, III C4) •

ENGA01: engineering knowledge (4)
ICHEME A2.2.2: Thermodynamics and transport (1)
ICHEME A 5.2.2: Communication (1)
UOA_1: Disciplinary Knowledge and Practice (4)
UOA_2: Critical Thinking (2)
UOA_5: Independence and Integrity (1)

No related assessments

Assessment


Coursework

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